THESIS ON INTRATHECAL DEXMEDETOMIDINE

Responds to commands only. Sluggish response to light glabellar tap or loud noise. Author information Copyright and License information Disclaimer. Materials and Methods The study was conducted after approval of ethical committee of the institution. Pain score was recorded using VRS scale. Different observers have recommended different doses of dexmedetomidine.

A number of adjuvants, such as clonidine and midazolam, and others have been studied to prolong the effect of spinal anesthesia. Effect of low dose dexmedetomidine or clonidine on the characteristic of bupivacaine spinal block. Sedation was assessed by a modified Ramsay sedation scale. Results were expressed as mean and standard deviation SD or number or percentages. They found a shorter onset of motor block and a prolongation in the duration of motor and sensory block with haemodynamic stability and lack of sedation [ 5 ]. Further testing was performed at min intervals until the recovery of S2 dermatome. Clonidine has been shown to significantly increase the duration of anaesthesia produced by hyperbaric or isobaric bupivacaine with good safety profile [ 1 — 3 ].

Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult

Various adjuvants have been used with local anesthetics in spinal anesthesia to avoid intraoperative visceral and somatic pain and to provide prolonged postoperative analgesia. According to previous few studies, as the dose is increased intrathecally, the iintrathecal of analgesia increased.

thesis on intrathecal dexmedetomidine

Aim To find out the optimum dose of dexmedetomidine to be used in lower abdomen surgery intrathecally. They were monitored with automated noninvasive blood pressure, pulse oximetry, and electrocardiogram.

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Optimal Dose of Intrathecal Dexmedetomidine in Lower Abdominal Surgeries in Average Indian Adult

A common problem during lower abdominal surgeries under spinal anesthesia is visceral pain, nausea, and vomiting. None of the patients showed any neurological deficit in follow up visits. All the analgesics supplemented were recorded. We found significant difference among the groups as far as the onset of sensory or motor blocks or time to reach T10 or the highest level is concerned in comparison to placebo.

Dexmedetomidine, a selective alpha2 adrenoceptor agonist, has been used as adjuvant to spinal anaesthesia.

A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine

Find articles by Adil Asghar. There was no significant difference in the type of surgery. Pruritus after intrathecal fentanyl is known but it was not significant in the present study. Activation of receptors in the brain and spinal cord inhibits neuronal firing and leads to sympatholytic effect, causing hypotension, bradycardia, sedation and analgesia [ 14 ].

Aim In this study we tried to find out the optimum dose of dexmedetomidine that should be used dexmeedetomidine an average built adult Indian population i.

A Comparative study of intrathecal dexmedetomidine and fentanyl as adjuvants to Bupivacaine

Effects of intrathecal midazolam on postoperative analgesia when added to a bupivacaine-clonidine mixture. Kruskal Wallis test for non-parametric data was dexmedetomidihe. Table 3 Side effects.

thesis on intrathecal dexmedetomidine

Visceral antinociceptive effects of spinal clonidine combined with morphine, enkephalin, or U50, H. Hala EA Eid et al. Brisk response to light glabellar tap or loud noise. Effect of dexmedetomidine added to spinal bupivacaine for urological procedure. Clonidine has been shown to significantly increase the duration of anaesthesia produced by hyperbaric or isobaric bupivacaine with good safety profile [ 1 — 3 ]. A simple and general model for traditional and modern hypothesis tests.

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Significant prolongation of analgesia and significantly less side effects leads us to conclude that 10 mcg of dexmedetomidine is the optimum dose. Results were expressed as mean and standard deviation SD or number or percentages. Theiss in the incidence of shivering with perioperative dexmedetomidine: Dexmedetomidine is more selective alpha 2 adrenoceptor agonist and has recently been used as adjuvant to intrathecal local anaesthesia [ 4 — 6 ] Previous animal [ 78 ] and human trials [ 5 ] suggest a 1: Effect of dexmedetomidine added to spinal intrathecl for urological procedure.

Intrathecal low dose hyperbaric bupivacaine-clonidine combination in outpatient knee arthroscopy: A Double Blind Controlled Study.

thesis on intrathecal dexmedetomidine

Patients allergic to drugs to be used in the study and those with co-existing neurological disorders, dexmedetomidinf, cardiac diseases, obesity and hypertension were excluded. Conclusion Dexmedetomidine significantly enhances the onset of sensory and motor block in comparison to placebo in a dose dependant manner and so is the duration of blocks and the anagesia provided. Controlled sedation with alpaxalone-alphadolone.

Dexmedetomidine as an intrathecal adjuvant for postoperative analgesia. The p-value of less than 0.

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